The Endocannabinoid System: Everything You Need to Know

Endocannabinoid System receptor locations on the human body using the Vitruvian man

What is the Endocannabinoid System?

The endocannabinoid system (ECS) is a complex cell-signaling system that plays a crucial role in regulating various physiological processes in the body, including pain, mood, appetite, immune function, and sleep. The ECS is made up of three main components: endocannabinoids, receptors, and enzymes.

What Are Endocannabinoids?

Endocannabinoids are molecules that the body produces naturally, similar in structure to the cannabinoids found in the cannabis plant. The two most well-known endocannabinoids are anandamide and 2-arachidonoylglycerol (2-AG). These molecules bind to receptors in the ECS, which are found on the surface of cells throughout the body.

How the Endocannabinoid System Works


The two main types of receptors in the ECS are CB1 and CB2 receptors.

CB1 receptors are primarily found in the central nervous system, while CB2 receptors are primarily found in the immune system. Endocannabinoids bind to these receptors and activate them, which in turn triggers a cascade of cellular events that lead to a specific physiological response.


Enzymes are responsible for breaking down endocannabinoids once they have fulfilled their purpose. The two main enzymes involved in this process are fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). FAAH breaks down anandamide, while MAGL breaks down 2-AG.

Why is the Endocannabinoid System So Important?

The ECS plays a crucial role in maintaining homeostasis, or balance, in the body. When the body is in a state of imbalance, such as during injury or disease, the ECS is activated to help bring the body back to a state of balance. For example, when there is inflammation in the body, the ECS is activated to help reduce inflammation and promote healing.

Research has shown that the ECS is involved in a wide range of physiological processes, and dysfunction in the ECS has been linked to a variety of diseases, including anxiety, depression, chronic pain, and cancer. This has led to a growing interest in the therapeutic potential of cannabinoids and the ECS.

So How Does CBD Help the Endocannabinoid System?

Cannabis compounds, such as CBD and THC, interact with the ECS by binding to its receptors. CBD, for example, has been found to inhibit the activity of FAAH, leading to an increase in anandamide levels. This can help to enhance the activity of the ECS, leading to potential therapeutic effects.

It is important to note that more research is needed to fully understand the complex mechanisms of the endocannabinoid system and how it interacts with different compounds, including CBD and THC.


The endocannabinoid system is a complex system that plays a crucial role in maintaining balance in the body. It is composed of endocannabinoids, receptors, and enzymes that work together to regulate various physiological processes.

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I am the owner and founder of CBD Review Lab. I started CBD Review Lab after having a positive experience with CBD and wanted to share my experience in hopes it would help others. I hope that this website is helpful to you in finding a CBD product that suits your needs. If you have any questions, please don’t hesitate to reach out.

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